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A Biomembrane Research Group, University of Murcia, in collaboration with the X-ray Crystallography of the Institute of Molecular Biology of Barcelona, has discovered a new cellular signaling pathway that will design new therapeutic strategies against pathological processes.
This new cell signaling pathway through protein kinase C facilitate planning future therapeutic approaches to control the activity of these proteins in disease processes in which they are involved.
Protein kinases C are a family of enzymes that are distributed in different body tissues and involved in numerous functions performed by cells, such as stimulating growth and differentiation.
In addition, these enzymes are involved in many pathological processes such as cancer, heart failure, lung disease and allergies, among others.
In the study, published in the scientific journal Proceedings of the National Academic of Sciences, USA "has solved the three dimensional structure of a fragment of protein kinase C bound to a lipid activator, naturally, is in the cell membrane.
Until now it was unknown that this lipid could directly activate these proteins.
The work was coordinated by Dr. Senen Carlini, a professor in the Department of Molecular Biology and component A research group at the University of Biomembranes Murcia.
Source: Universidad de Murcia
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