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The research output of the Catholic University of Murcia, which has been as intense as varied in topics and researchers, has been led by Professor of Biology of Development Juan Carlos Izpisua, who has published in 2017 in the scientific journals with the greatest impact in the world nine. articles derived from the research projects promoted by the UCAM.
The Catholic University of Murcia has increased again in 2017 its scientific impact, being a global reference in the field of regenerative medicine the Professor of Biology of Development of the UCAM, Juan Carlos Izpisua, who has published this year a total of nine articles scientists, derived from the projects promoted and funded by the UCAM, in leading journals such as Cell, Nature and Science, among others.
Of all of them, the one that has had the greatest impact is that published by the journal Cell in January, which showed that human stem cells were capable of integrating into a pig embryo and became precursors of different tissues.
This result laid the first stone to know that we can use gene editing techniques and pluripotent cells to generate human organs for transplants.
This article is among those considered 'highly cited' and, therefore, one of the best in its field.
Undoubtedly, one of the world's leading lines of research in the area of ​​genetics is the study of the epigenome, being advanced by the journals Sicence and Cell the results of the studies of Dr. Izpisua and his team with collaboration from the UCAM .
The most recent, published in Cell this December, has marked a before and after in the cure of diseases such as diabetes or muscular dystrophy, by using the CRISPR / Cas9 technique without cutting the DNA.
It shows that, by modifying the marks that the passage of time and environmental factors generate in DNA (epigenetics), certain diseases can be reversed.
While there have been nine articles with high impact published during this year 2017, there are a total of 23 disseminated as a result of the collaboration of Dr. Izpisua Belmonte with the Catholic University of Murcia, especially highlighting the entitled 'In vivo Amelioration of Age-Associated Hallmarks by Partial Reprograming CELL 'published in December 2016 and considered as "popular" in the scientific world due to the very high number of citations received.
On these results, the Vice Chancellor of Research of the UCAM, Estrella Núñez, has assured that "the path marked by our president, José Luis Mendoza, to work with Dr. Izpisua is a privilege, since it allows us to address projects that contribute to the resolution of some of the great challenges of humanity, such as the cure of certain diseases. "
It has also materialized as essential elements to position the UCAM, and therefore the Region of Murcia, at the forefront of knowledge: "quality and continuous improvement in the development of work, collaborations with researchers of international prestige and major investments in research "
Zika and atopic demartitis
On the other hand, and also in 2017, researchers from the UCAM and the University of Hong Kong discovered that a molecule, used so far as an antibiotic, can be used as a potent drug to combat the dangerous consequences of the Zika virus, associated with serious neurological disorders, paralysis, head deformations and even the death of a fetus.
After the success of the test of the compound (novobiocin) in mice, with an efficacy of 100% cure, researchers now work on fine tuning with the necessary dose to apply in humans to achieve the same response.
The scientific journal Journal of the American Medical Association (JAMA) has echoed another of the most outstanding research of the year, developed by researchers from the UCAM together with the Aesthetic Dermatological Center of Alicante and the University Hospital of Vinalopó in Elche.
It states that some diseases of unknown origin may be caused by the bacteria that inhabit our intestine.
It shows that the modification of the intestinal flora has the same effect as the use of corticosteroids in the cure of diseases such as atopic dermatitis.
Source: UCAM
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