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UCAM researchers patent a new biomaterial to regenerate bone (24/10/2019)

Among its advantages is that it does not present rejection and is easily fixed in the tissue where it is implanted.

With it, avoid having to remove bone tissue from another part of the patient's own body or use donor bone when repairing any bone defect.

Currently, when the reconstruction of a bone is necessary, the most commonly used technique is the autograft, which consists of taking bone tissue from another area of ​​the skeleton (donor area) of the same patient, either of the same bone or of another, but This procedure has some disadvantages or disadvantages such as the sacrifice of the donor zone that can cause a disorder to the patient in up to 25% of the cases, in addition to the limited availability when large amounts of bone are needed to graft.

Or also through an allogeneic graft (from a deceased donor), in this case the main drawback is the possibility of transmission of donor diseases.

Given this situation, a group of researchers from UCAM, belonging to the Tissue-Biomaterial and Tissue Tissue Regeneration and Repair Laboratory, led by traumatologist and professor Luis Meseguer-Olmo, began investigating obtaining biocompatible rough surface porous materials and bioactive for its use as "bone graft substitutes" in those clinical situations where biological stimuli are required to achieve bone regeneration.

From these investigations the patent emerges, a formula for obtaining a new biomaterial whose main components are calcium a-sulfate hemihydrate, ß-tricalcium phosphate and dicalcium silicate, and which could be applied for bone reconstructive surgery in general, in the medical fields of traumatology and orthopedic surgery, oral surgery, maxillofacial surgery and neurosurgery.

Among the advantages of this new material, which has been tested on animals, it stands out that it does not present rejection, it is easily fixed to the material where it is implanted and the production cost is much lower than that of current biomaterials, so its application would involve significant savings compared to the techniques currently used.

Similarly, notes Dr. Meseguer-Olmo that "the material has been shown to be biocompatible, not showing signs of cytoxicity; in addition, it is able to absorb proteins on its surface and something inside, and be highly bioactive, which facilitates the adhesion and cell proliferation on the surface of the material ".

In addition, this new compound retains the temperature at room level (22 ° C) during the entire setting process, which prevents it from causing cellular damage, contrary to what happens with the bone cements used to fix some components of the prosthesis , which produce high temperatures while consolidating.

Currently, UCAM, through its Office of Technology Transfer (OTRI), is processing the registration of 10 new patents nationally and internationally, mainly in the area of ​​health sciences, sports and food.

In order for society to benefit from the knowledge protected in patents, it is necessary to license the rights of its exploitation to companies that are capable of producing new products and introducing them into the market.

Source: UCAM

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